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Cushing's disease is a condition in which the adrenal glands overproduce certain hormones. There are three types of Cushing's disease, each of which has a different cause. The most common cause of Cushing's disease is a pituitary gland tumor. Cushing's disease may also be the result of a benign or malignant tumor of the adrenal gland itself, or may be caused from the excessive administration of an oral or injectable steroid. Clinical signs, treatment, and prognosis are discussed.
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Cushing's disease, or hyperadrenocorticism, is the overproduction of cortisol hormone by a dog's body. The clinical signs of Cushing's disease are similar, regardless of the underlying cause of the disease. However, it is essential to identify the type of Cushing's disease as the treatment and prognosis differ slightly depending upon the form of the disease.
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Treatment for Cushing’s disease using mitotane involves two phases: initiating phase and maintenance phase. Monitoring your dog’s food and water intake is very important. This handout provides detailed treatment instructions for dogs prescribed mitotane. Follow your veterinarian’s instructions carefully and report changes in your dog’s behavior to your veterinarian.
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A cutaneous histiocytoma is a common benign (harmless) tumor of the skin in dogs, typically younger ones. Their development, appearance, diagnosis, and treatment are explained in this handout.
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Cutaneous histiocytosis is an uncommon condition in dogs. It is a non-cancerous increase in the number of reactive cells (histiocytes) caused by an immune system dysfunction. It generally manifests as multiple bumps and nodules confined to the dog's skin. The clinical signs, diagnosis, and treatment of this condition are explained in this handout.
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Skin cancers are common in cats, but cutaneous lymphoma is relatively uncommon. Less than 2% of lymphoma cases in cats occur in the skin. As the disease progresses, the skin becomes thickened, reddened, ulcerated, and may ooze fluid. The most common locations to find lesions include the junction between mucus membranes and the skin. Unfortunately, feline cutaneous lymphoma is considered incurable. Surgical removal can be attempted for solitary lesions, although the tumor often returns to the area or will have spread elsewhere in the body already
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Systemic lymphoma is a very common cancer in dogs, but the cutaneous form is quite rare. Current statistics suggest that cutaneous lymphoma accounts for only about 5% of canine lymphoma cases. The disease can present in a variety of lesions, including ulcers, nodules, red patches, and areas of hair loss and skin scaling. Because not very much is known about canine cutaneous lymphoma, there are no standard treatment protocols and the prognosis is poor.
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Cutaneous papillomatosis is the development of papillomas (non-cancerous growths, or warts) caused by the papillomavirus and affects many pet birds. Commonly affected species are finches, canaries, cockatiels, budgerigars, and African grey parrots. The clinical signs and treatment for this condition are explained in this handout.
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Cuterebra are botflies that spend the larvae stage of their lifecycle within rodent or rabbit hosts and can accidentally infect dogs. They enter through the nose, mouth or a skin wound. They usually develop a cyst under the skin that can be located as it enlarges and often a breathing hole can be seen. The larva (warble) will leave the dog when it is ready to form a pupa but it will often leave behind a secondary bacterial skin infection or abscess in the empty cyst. Rarely, the larva/cuterebra migrate aberrantly through the dog causing inflammation and damage to different tissues, including the brain and eyes, and even potentially cause a severe systemic inflammatory response. Treatment depends on what damage has been done and can include removal of the warble, debridement or removal of the cyst, antibiotics and symptomatic and supportive treatment of the results of aberrant migration. Prognosis is generally good if only the skin is involved. Cuterebra infection can not be prevented easily, so monitoring the dog regularly for signs is important.
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Cuterebra is the scientific name for the North American rabbit or rodent botfly. Cats are accidental hosts of Cuterebra larvae, and they are rarely evident from external skin inspection. A hole enlarges when the warble has matured, often leading to an infected empty cyst. Treatment depends on when the condition is discovered, and in many cases, antibiotics are used to treat secondary infections.