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The pancreas is an abdominal organ responsible for regulating blood glucose (endocrine function) and releasing enzymes that aid in digestion (exocrine function). Problems with the pancreas can cause a variety of conditions, discussed here. Clinical signs and tests are outlined.
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Finding the cause of a pet's seizures can be difficult. Screening usually starts with a complete history and physical examination, followed by blood and urine tests to look for underlying diseases that can cause seizures. If the cause still cannot be identified, it is possible that they originate within the brain itself and further neurologic testing might be advised.
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Sneezing and nasal discharge can occur for many different reasons, including infection, allergy, foreign body, and tumors. A thorough history and physical exam is the first step in diagnosing the cause of sneezing/nasal discharge. Initial screening tests are outlined, including CBC, biochemistry profile, urinalysis, and coagulation testing. Specific tests and more advanced diagnostics are also summarized.
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Unexplained bleeding is worrisome because it suggests a problem with the body’s blood clotting or coagulation system. Disorders of the coagulation system can arise for many reasons, including shortages of coagulation factors (clotting proteins), a shortage of platelets (a type of blood cell), defective platelets, and serious systemic disease affecting the whole body.
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A pet with vomiting may suffer from an isolated incident, or it could be a sign of more severe problems. If the cause for vomiting is not obvious from history and examination, screening tests may be done to eliminate possible causes and determine a treatment plan. Results can also provide a prognosis for recovery and long-term outlook.
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Weakness can be caused by many different problems and can involve a variety of body systems. Finding the cause of your pet’s weakness starts with a complete history and physical examination. The most commonly recommended screening tests for weakness include complete blood count, serum biochemistry profile, urinalysis, and in a dog, total thyroxine. Additional tests may be recommended based on the results of these screening tests.
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Weight loss in dogs can be caused by many conditions including inadequate intake to meet energy requirements, poor quality nutrition, and many different medical conditions. Testing for weight loss starts with a thorough history and physical exam. If the cause of weight loss is not clear, then screening tests including a CBC, biochemistry, urinalysis, and fecal tests are performed to further investigate. Based on the results of these tests, more specific diagnostic tests such as imaging, bile acids, or ACTH stimulation may be needed to determine the reason for the weight loss.
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The most common disorder of the thyroid gland in cats is hyperthyroidism. Diagnosis of hyperthyroidism includes screening the hormone output of the thyroid as well as screening for other systemic diseases. This is achieved by running a complete blood count, biochemistry panel, urinalysis, and total T4 (tT4). Additional tests may be required. Cats undergoing treatment for hyperthyroidism will have regular blood monitoring to ensure the disease is under control.
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The most common disorder of the thyroid gland in dogs is hypothyroidism. Diagnosis of hypothyroidism includes a complete blood count, biochemistry profile, urinalysis, and thyroid-related hormones. Mild anemia, elevated cholesterol and mildly elevated liver and kidney enzymes are supportive of a diagnosis of hypothyroidism. A combination of clinical signs and measurements of total T4, free T4 by equilibrium dialysis, and thyroid stimulating hormone (TSH) is generally used to confirm a diagnosis.
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Trypsin-like immunoreactivity (TLI) is a blood test that measures the amount of a pancreatic proenzyme called trypsinogen. This measurement correlates with the amount of pancreatic enzymes released into the intestine to aid in digestion. A low measurement indicates exocrine pancreatic insufficiency. Concurrent pancreatitis or tests done shortly after a meal may temporarily increase this measurement to a normal value (false negative).