Educational Articles
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Fibrosarcomas are the third most common oral tumor in dogs and arise from the fibrous and connective tissues of the oral cavity. These tumors are very invasive locally and are often difficult to manage, Diagnosis is based on biopsy. Treatment involving surgery and radiation provide the longest survival times.
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Oral melanomas are the most common malignant oral tumor in dogs. Melanomas usually present as a mass in the mouth and may be melanotic (pigmented) or amelanotic (non-pigmented). These tumors are both locally invasive and have a high tendency to metastasize to other organs. Full staging including CT scanning is recommended to determine the extent of the disease.
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Like humans, benign and malignant tumors occur in dogs’ mouths. Peripheral odontogenic fibromas (POF) are the most common benign tumors while oral melanomas, squamous cell carcinomas, and fibrosarcomas are the most prevalent malignant tumors in dogs. Diagnosis may be performed via fine needle aspiration or biopsy. Spread to mandibular lymph nodes does occur. Fine needle aspiration of the lymph nodes is recommended when malignant tumors are suspected. Tumor staging including laboratory testing as well as CT imaging helps to plan therapy.
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This handout discusses some of the more common forms of oral tumors in pets. Highlighted are Papillomas (“Warts”) and Fibropapillomas, both of wish are caused by viral infection. Clinical signs, diagnostic methods, and treatment options are highlighted.
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Osteosarcomas are somewhat rare in cats and progress slowly. Osteosarcoma is very painful. The most common location where osteosarcomas develop in cats is the hindlimb. Amputation is by far the most common treatment. Chemotherapy is not generally pursued without evidence of metastasis, given the relatively long-term control with surgery alone.
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Osteosarcoma, or bone cancer, is common in large breed dogs and is very aggressive, with upwards of 90-95% of patients having micrometastasis. Osteosarcoma is very painful. Lameness or a distinct swelling may be noted. Amputation is by far the most common treatment with chemotherapy following surgery. Radiation therapy may also be an option.
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Rarely, ovarian tissue can be left behind when a dog is spayed. This leads to the ongoing secretion of hormones such as estrogen and progesterone that can result in a dog continuing to have a heat cycle. Ovarian remnants are difficult to diagnose, but vaginal cytology combined with hormone testing can be used to confirm the presence of functional ovarian tissue. Surgical treatment is typically recommended to prevent other health conditions from developing.
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Ovarian tumors are quite rare in North American pets, mainly due to routine spaying practices. This handout discusses ovarian tumors in dogs and cats. The various forms of ovarian tumors, clinical signs, diagnosis, treatment, and prognosis of this cancer are outlined.
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Primary pancreatic tumors are rare in dogs and cats. Exocrine tumors include adenomas and adenocarcinomas, and endocrine tumors include insulinomas, gastrinomas, and glucagonomas. Insulinomas are the most common type of pancreatic tumor, followed by adenocarcinomas. Both tumors are more common in dogs than cats. Large breed dogs and Siamese cats may be predisposed. Insulinomas are usually diagnosed with the finding of hypoglycemia with normal to high insulin on bloodwork and concomitant clinical signs. Adenocarcinomas typically go undetected until the clinical signs of metastasis are evident. For both tumors, diagnostic imaging and exploratory surgery with tumor removal (or biopsy) and histopathology are needed for a definitive diagnosis. Insulinomas can be treated with surgery and chemotherapy. Surgery is possible with adenocarcinomas, but as the cancer is more diffuse and has usually metastasized by the time of diagnosis, the prognosis is poorer. Chemotherapy and radiation therapy are ineffective in the treatment of adenocarcinomas. Given the high rate of metastasis with these tumors, staging is recommended prior to surgery.
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Parathyroid tumors are uncommon in dogs and cats. Benign adenomas occur more often than malignant tumors. Keeshonds appear to have a genetic predisposition to developing parathyroid tumors, but no breed or genetic relationship has been established in cats. Pets may exhibit signs of lethargy, little or no appetite, vomiting, and muscle twitching. Diagnosis is confirmed with PTH testing and ultrasound of the neck region after hypercalcemia is observed on bloodwork. Surgery to remove the affected gland(s) is the typical treatment, but ultrasound-guided ablation may be pursued. Careful monitoring of calcium levels post-surgery is important, as some pets may develop transient hypocalcemia and require calcium supplementation. Prognosis is excellent, and the metastatic rate for these tumors is extremely low.
