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Cutaneous histiocytosis is an uncommon condition in dogs. It is a non-cancerous increase in the number of reactive cells (histiocytes) caused by an immune system dysfunction. It generally manifests as multiple bumps and nodules confined to the dog's skin. The clinical signs, diagnosis, and treatment of this condition are explained in this handout.
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Systemic lymphoma is a very common cancer in dogs, but the cutaneous form is quite rare. Current statistics suggest that cutaneous lymphoma accounts for only about 5% of canine lymphoma cases. The disease can present in a variety of lesions, including ulcers, nodules, red patches, and areas of hair loss and skin scaling. Because not very much is known about canine cutaneous lymphoma, there are no standard treatment protocols and the prognosis is poor.
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Cuterebra are botflies that spend the larvae stage of their lifecycle within rodent or rabbit hosts and can accidentally infect dogs. They enter through the nose, mouth or a skin wound. They usually develop a cyst under the skin that can be located as it enlarges and often a breathing hole can be seen. The larva (warble) will leave the dog when it is ready to form a pupa but it will often leave behind a secondary bacterial skin infection or abscess in the empty cyst. Rarely, the larva/cuterebra migrate aberrantly through the dog causing inflammation and damage to different tissues, including the brain and eyes, and even potentially cause a severe systemic inflammatory response. Treatment depends on what damage has been done and can include removal of the warble, debridement or removal of the cyst, antibiotics and symptomatic and supportive treatment of the results of aberrant migration. Prognosis is generally good if only the skin is involved. Cuterebra infection can not be prevented easily, so monitoring the dog regularly for signs is important.
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Blue-green algae, also called cyanobacteria, are found in fresh and brackish water of ponds and lakes. These microscopic bacteria can also grow in backyard fountains, garden pots, bird baths, and anywhere water is stagnant. Regardless of where they are found, cyanobacteria can be dangerous.
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Cyanocobalamin (vitamin B12 or cobalamin) is a vitamin supplement used to treat systemic deficiencies. It can be given through a subcutaneous injection or oral tablet. The injection may sting temporarily, but otherwise is very safe. If a negative reaction occurs, call your veterinary office.
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Cyanosis is a bluish discoloration of the skin and mucous membranes of the body caused by inadequate oxygen levels. Cyanosis is an emergency, and the root cause may be life-threatening and may or may not be reversible. Once back home, homecare instructions must be followed carefully.
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Cyclophosphamide is given by mouth or injection and is used off label to treat various cancers such as lymphoma, leukemia, carcinoma, and sarcoma. Common side effects include hair loss and hair coat changes. Do not use in pets that are allergic to it or that cannot be sufficiently monitored during treatment, are pregnant or lactating, have urinary obstruction, infection, bone marrow dysfunction, or have had an episode of blood in the urine that is not associated with a bladder infection. If a negative reaction occurs, please call your veterinary office.
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Cyclosporine ophthalmic ointment is an immunosuppressant used in the treatment of eye diseases suspected to be immune-related, including keratoconjunctivitis sicca (KCS) and other inflammatory conditions of the eye. Cyclosporine comes as an ophthalmic ointment but may sometimes be compounded into a higher concentration ophthalmic solution for pets not responding to the ointment. It is important to remember that it may take days to weeks to notice improvement. Do not stop giving the medication without asking your veterinarian. If signs of serious side effects or immune suppression occur, contact your veterinarian immediately.
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Cyclosporine is given by mouth and is used to treat atopic dermatitis in dogs and cats. It has also been used off-label to treat other types of immune-mediated conditions. Give as directed. The most common side effects include stomach upset, such as vomiting, diarrhea, and decreased appetite. Do not use in pets with severe infections, a history of cancer, allergies to the medication, that are nursing or pregnant, or in pets younger than six months old. If a negative reaction occurs, contact your veterinarian.
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Cyproheptadine is given by mouth and is used off label to treat allergic skin conditions, certain toxicities, and to stimulate appetite. Give as directed by your veterinarian. Common side effects include sleepiness, increased appetite, and dry mouth. Do not use in pets that are allergic to it or pets undergoing skin allergy testing within the next two weeks. If a negative reaction occurs, please call your veterinary office.
